Abstract The last decades have seen a major gain in understanding the action of cannabinoids and the endocannabinoid system in reward processing and the development of addictive behavior. Cannabis-derived psychoactive…
Keyword: Cannabinoid/s
Cannabinoids and their therapeutic applications in mental disorders
Abstract Mental disorders represent a significant public health burden worldwide due to their high prevalence, chronically disabling nature, and substantial impact on quality of life. Despite growing knowledge of the…
Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies
Abstract Melanoma is the fourth most common type of cancer diagnosed in Australians after breast, prostate, and colorectal cancers. While there has been substantial progress in the treatment of cancer…
Cannabinoids in the descending pain modulatory circuit: Role in inflammation
Please use this link to access this publication. Abstract The legalization of cannabis in some states has intensified interest in the potential for cannabis and its constituents to lead to…
Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics
Please use this link to access this publication. Abstract Prolonged status epilepticus (SE) in humans causes high mortality and brain inflammation–associated neuronal injury and morbidity in survivors. Currently, the only…
Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy
Please use this link to access this publication. Abstract Purpose Cannabinoids have been shown to exert analgesic and anti-inflammatory effects, and the effects of cannabinoids are mediated primarily by cannabinoid…
Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users
Abstract Background: The widespread use of synthetic cannabinoids (SCs) among youth has become an important public health problem. Several life-threatening side effects of SC have been reported, including cardiovascular, gastrointestinal,…
Membrane cholesterol dependence of cannabinoid modulation of glycine receptor
Please use this link to access this publication. Abstract Cannabinoids exert therapeutic effects on several diseases such as chronic pain and startle disease by targeting glycine receptors (GlyRs). Our previous…
Structural connectivity in adolescent synthetic cannabinoid users with and without ADHD
Please use this link to access this publication. Abstract Synthetic cannabinoids (SC) have become increasingly popular in the last few years, especially among adolescents. Given ADHD is overrepresented in patients…
Peripheral Endogenous Cannabinoid Levels Are Increased in Schizophrenia Patients Evaluated in a Psychiatric Emergency Setting
ABSTRACT Background: The endogenous cannabinoid system mediates the psychoactive effects of cannabis in the brain. It has been argued that this system may play a key role in the pathophysiology of…