Abstract In the process of neonatal encephalopathy, oxidative stress and neuroinflammation have a prominent role after perinatal asphyxia. With the exception of therapeutic hypothermia, no therapeutic interventions are available in…
Keyword: Cannabinoid/s
Monitoring Perinatal Exposure to Cannabis and Synthetic Cannabinoids
Please use this link to access this publication. Abstract Purpose: Drug use during pregnancy is a critical global challenge, capable of severe impacts on neonatal development. However, the consumption of…
Cannabinoid type-2 receptor agonist, inverse agonist, and anandamide regulation of inflammatory responses in IL-1β stimulated primary human periodontal ligament fibroblasts
Please use this link to access this publication. Abstract Objective The aim of this study is to understand the role of cannabinoid type 2 receptor (CB2R) during periodontal inflammation and…
Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Abstract Preclinical studies highlighted that compounds targeting cannabinoid receptors could be useful for developing novel therapies against neurodegenerative disorders. However, the chronic use of orthosteric agonists alone has several disadvantages,…
Cannabinoids for the Neuropsychiatric Symptoms of Dementia: A Systematic Review and Meta-Analysis
ABSTRACT Background: In 2016, the global number of individuals living with dementia was 43.8 million, representing a 117% increase from 1990—mainly due to increases in aging and population growth. Up…
Comparison of Efficacy of Cannabinoids versus Commercial Oral Care Products in Reducing Bacterial Content from Dental Plaque: A Preliminary Observation
Please use this link to access this publication. Abstract Background Dental plaque is a complex biofilm that gets formed on the teeth and acts as a reservoir of different microbes….
Therapeutic use of cannabis and cannabinoids: an evidence mapping and appraisal of systematic reviews
Abstract Background Although cannabis and cannabinoids are widely used with therapeutic purposes, their claimed efficacy is highly controversial. For this reason, medical cannabis use is a broad field of research…
Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation
Please use this link to access this publication. Abstract Purpose: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is associated with daily marijuana use and is also increasing in…
Cannabinoids for fibromyalgia pain: a critical review of recent studies (2015–2019)
Abstract Introduction Fibromyalgia is a chronic health condition characterized by widespread, severe musculoskeletal pain that affects an estimated 5–7% of the global population. Due to the highly comorbid nature of…
Cannabinoids and the endocannabinoid system in anxiety, depression, and dysregulation of emotion in humans
Please use this link to access this publication. Abstract Purpose of review This review is to summarize most recent evidence published in the last 18 months on medical and recreational…