Please use this link to access this publication. Abstract For millennia, Cannabis sativa has served diverse roles, from medicinal applications to recreational use. Despite its extensive historical use, only a fraction of…
Condition: Epilepsy
Assessing the neuroprotective benefits of Cannabis sativa in epilepsy management
Abstract Epilepsy is one of the most common neurological conditions worldwide. Cannabinoids, particularly cannabidiol (CBD) and tetrahydrocannabinol (THC), have demonstrated therapeutic potential in the treatment of epilepsy due to their…
Cannabis use, sleep and mood disturbances among persons with epilepsy – A clinical and polysomnography study from a Canadian tertiary care epilepsy center
Highlights Prospective study with sleep and mood assessment in people with epilepsy (PWE) reporting cannabis use. Self-reported sleep quality, but not sleep quality and quantity from PSG was significantly better…
Cannabis-based products for pediatric epilepsy: A systematic review
Summary Objective To assess the benefits and harms of cannabis-based products for pediatric epilepsy. Methods We identified in this living systematic review randomized controlled trials (RCTs) and nonrandomized studies (NRSs)…
Cannabinoids in treatment-resistant epilepsy: A review
Please use this link to access this publication. Abstract Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been…
Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence
Abstract Review evidence for cannabinoids as adjunctive treatments for treatment-resistant epilepsy. Systematic search of Medline, Embase and PsycINFO was conducted in October 2017. Outcomes were: 50%+ seizure reduction, complete seizure freedom;…
Cannabis for the Treatment of Epilepsy: an Update
Please use this link to access this publication. Abstract Purpose of Review For millennia, there has been interest in the use of cannabis for the treatment of epilepsy. However, it is only…
CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood
Please use this link to access this publication. Abstract Obsessive compulsive disorder (OCD) is a comorbid condition of epilepsy and often adds to the burden of epilepsy. Both OCD and epilepsy are…
An Australian nationwide survey on medicinal cannabis use for epilepsy: History of antiepileptic drug treatment predicts medicinal cannabis use
Abstract Epilepsy Action Australia conducted an Australian nationwide online survey seeking opinions on and experiences with the use of cannabis-based products for the treatment of epilepsy. The survey was promoted via…
Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex
Summary Objective Tuberous sclerosis complex (TSC) is an autosomal-dominant genetic disorder with highly variable expression. The most common neurologic manifestation of TSC is epilepsy, which affects approximately 85% of patients,…