ABSTRACT Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However, their use can result in a number of unwanted side-effects…
Keyword: Cannabinoid/s
Cannabinoids in the Treatment of Insomnia Disorder: A Systematic Review and Meta-Analysis
Please use this link to access this publication. Abstract Background Insomnia is associated with significant comorbidity, disability and impact on quality of life and, despite advances in pharmacotherapy and psychotherapy,…
Spinal cannabinoid receptor 2 activation reduces hypersensitivity associated with bone cancer pain and improves the integrity of the blood–spinal cord barrier
Abstract Background Disruption of the blood–spinal cord barrier (BSCB) can facilitate inflammation that results in pain hypersensitivity. Proinflammatory cytokines produced by activated microglia and astrocytes damage the BSCB. This study aims…
Cannabinoids in Dermatology: Hope or Hype?
Please use this link to access this publication. Abstract Cannabinoids (CBDs) represent a diverse class of chemicals that may be beneficial in the treatment of various skin diseases due to…
Effects of Cannabinoids on Female Sexual Function
ABSTRACT Introduction With the legalization of both medical and recreational marijuana in some countries and a few US states, its use has become more widely prevalent. Both exogenous cannabinoids such…
Cannabinoid effects on responses to quantitative sensory testing among individuals with and without clinical pain: a systematic review
Please use this link to access this publication. Abstract There has been an explosion of interest in the utility of cannabinoids as potential analgesics. This systematic review critically synthesizes the…
Efficacy and acceptability of cannabinoids for anxiety disorders in adults: A systematic review & meta-analysis
Please use this link to access this publication. Abstract Objective The aim of this study was to assess the efficacy and acceptability of cannabinoids for the treatment of anxiety disorders. Methods For…
Adverse effects of cannabinoids
ABSTRACT Cannabidiol is a cannabinoid-derived product that has recently been approved for the treatment of pharmacoresistant seizures in patients with epileptic encephalopathies such as Dravet Syndrome and Lennox-Gastaut Syndrome. Short-term…
The Role of Atypical Cannabinoid Ligands O-1602 and O-1918 on Skeletal Muscle Homeostasis with a Focus on Obesity
Abstract O-1602 and O-1918 are atypical cannabinoid ligands for GPR55 and GPR18, which may be novel pharmaceuticals for the treatment of obesity by targeting energy homeostasis regulation in skeletal muscle….
Prevalence of Cannabis Withdrawal Symptoms Among People With Regular or Dependent Use of Cannabinoids
Please use this link to access this publication. Abstract Importance Cannabis withdrawal syndrome (CWS)—a diagnostic indicator of cannabis use disorder—commonly occurs on cessation of heavy and prolonged cannabis use. To date,…