Summary Human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors CB1 and CB2. Their high sequence similarity, low agonist selectivity, and lack of activation and…
Keyword: Cannabinoid receptor 1 (CB1)
Targeting Cannabinoid Receptors: Current Status and Prospects of Natural Products
Abstract Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a critical role in numerous human physiological and pathological conditions. Thus, considerable efforts have been made to…
Cannabinoids and Cannabinoid Receptors: The Story so Far
Abstract Like most modern molecular biology and natural product chemistry, understanding cannabinoid pharmacology centers around molecular interactions, in this case, between the cannabinoids and their putative targets, the G-protein coupled…
The Chemistry of Cannabis and Cannabinoids
Abstract The science of cannabis and cannabinoids encompasses a wide variety of scientific disciplines and can appear daunting to newcomers to the field. The encroachment of folklore and ‘cannabis culture’…
Brain imaging of cannabinoid type I (CB1) receptors in women with cannabis use disorder and male and female healthy controls
Abstract Cannabis effects are predominantly mediated by pharmacological actions on cannabinoid type 1 (CB1) receptors. Prior positron emission tomography (PET) studies in individuals who use cannabis included almost exclusively males….
Cannabis sativa L. as a Natural Drug Meeting the Criteria of a Multitarget Approach to Treatment
Abstract: Cannabis sativa L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes….
The Behavioral Sequelae of Cannabis Use in Healthy People: A Systematic Review
Abstract Background: Cannabis is known to have a broad range of effects on behavior, including experiencing a “high” and tranquility/relaxation. However, there are several adverse behavioral sequalae that can arise…
Cannabis: A Toxin-Producing Plant with Potential Therapeutic Uses
Abstract For thousands of years, Cannabis sativa has been utilized as a medicine and for recreational and spiritual purposes. Phytocannabinoids are a family of compounds that are found in the cannabis plant,…
Association of Cannabis Use During Adolescence With Neurodevelopment
Abstract Importance Animal studies have shown that the adolescent brain is sensitive to disruptions in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral effects. However, few studies have investigated ties…
Adverse Effects of Recreational and Medical Cannabis
Abstract Purpose of Review: This comprehensive review discusses the adverse effects known today about marijuana, for either medical or recreational use. It reviews the role of cannabis in the treatment…