Condition: Schizophrenia


From the Clinic to the Laboratory, and Back Again: Investigations on Cannabinoids and Endocannabinoid System Modulators for Treating Schizophrenia

Abstract The present mini-review focuses on animal models of schizophrenia that have explored the effects of cannabidiol (CBD; a non-psychoactive component of cannabis) or the pharmacological manipulation of the endocannabinoid…

Association between formal thought disorder and cannabis use: a systematic review and meta-analysis

Abstract Formal thought disorder (FTD) is a multidimensional syndrome mainly occurring along the psychosis continuum. Cannabis use is known to increase symptoms of psychosis, particularly positive symptoms. However, the impact…

Prospects for the Use of Cannabinoids in Psychiatric Disorders

Please use this link to access this publication. Abstract Increasing evidence suggests an essential role of the endocannabinoid system in modulating cognitive abilities, mood, stress, and sleep. The psychoactive effects…

The Cannabinoid CB1 Receptor in Schizophrenia

Please use this link to access this publication. Abstract Converging lines of evidence from epidemiological, preclinical, and experimental studies indicate that the endocannabinoid system may be involved in the pathophysiology…

Cannabis Cessation, Inflammatory Markers and Schizophrenia

Please use this link to access this publication. Abstract Objective A dysbalance of the immune system in schizophrenia has been largely described but few studies have investigated the impact of…

Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia

Abstract Cannabis use disorder (CUD) occurs at high rates in schizophrenia, which negatively impacts its clinical prognosis. These patients have greater difficulty quitting cannabis which may reflect putative deficits in…

Cannabis use selectively modulates circulating biomarkers in the blood of schizophrenia patients

Abstract Cannabis use disorder is frequent in schizophrenia patients, and it is associated with an earlier age of onset and poor schizophrenia prognosis. Serotonin 2A receptors (5-HT2AR) have been involved…

Risk-thresholds for the association between frequency of cannabis use and the development of psychosis: a systematic review and meta-analysis

Abstract BackgroundEpidemiological studies show a dose–response association between cannabis use and the risk of psychosis. This review aimed to determine whether there are identifiable risk-thresholds between the frequency of cannabis…

Cannabis induced psychosis: A systematic review on the role of genetic polymorphisms

Abstract Objective Cannabis sativa is a recreational drug commonly consumed in Europe and is getting popularity for both recreational and therapeutic use. In some individuals, the use of cannabis leads to psychotic…

Cannabis and Psychosis: Recent Epidemiological Findings Continuing the “Causality Debate”

Abstract Nonmedical (“recreational”) cannabis use and cannabis laws have changed over the past two decades in the United States (1) and the rest of the world (2). Increasing use, especially…